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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPX2
All Species:
13.64
Human Site:
S218
Identified Species:
30
UniProt:
Q9ULW0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9ULW0
NP_036244.2
747
85653
S218
E
E
Q
E
L
E
K
S
M
K
M
Q
Q
E
V
Chimpanzee
Pan troglodytes
XP_001153533
746
85517
S217
E
E
Q
E
L
E
K
S
M
K
M
Q
Q
E
V
Rhesus Macaque
Macaca mulatta
XP_001109645
746
85683
S217
E
E
Q
E
L
E
K
S
M
K
M
Q
Q
E
V
Dog
Lupus familis
XP_850934
748
86144
R219
E
E
Q
E
L
E
K
R
M
K
M
Q
Q
E
V
Cat
Felis silvestris
Mouse
Mus musculus
NP_082385
745
85876
R220
E
E
Q
E
I
E
K
R
L
R
M
Q
Q
E
V
Rat
Rattus norvegicus
NP_001101260
744
85432
S218
E
E
Q
E
L
E
K
S
L
R
M
Q
Q
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516385
623
69684
Q206
Q
P
R
T
P
S
F
Q
T
K
G
R
L
R
P
Chicken
Gallus gallus
NP_989768
739
85048
Q210
K
L
K
S
T
E
E
Q
E
L
E
K
M
Q
Q
Frog
Xenopus laevis
NP_001086751
715
81991
A212
M
K
V
A
I
S
G
A
G
Q
P
V
K
N
F
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798362
948
108486
A349
N
K
S
S
Q
S
P
A
L
K
K
R
R
V
S
Poplar Tree
Populus trichocarpa
XP_002327911
811
91572
K240
S
S
Q
V
K
G
I
K
P
A
S
V
K
K
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97.5
90.3
N.A.
79.2
79.1
N.A.
40.1
57.5
53.8
N.A.
N.A.
N.A.
N.A.
N.A.
31.6
Protein Similarity:
100
99.3
98.6
93.9
N.A.
87.6
87.4
N.A.
53
72.5
70
N.A.
N.A.
N.A.
N.A.
N.A.
49.4
P-Site Identity:
100
100
100
93.3
N.A.
73.3
86.6
N.A.
6.6
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
26.6
40
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
20.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
39.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
19
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
55
55
0
55
0
64
10
0
10
0
10
0
0
55
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
10
10
0
10
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
19
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
10
19
10
0
10
0
55
10
0
55
10
10
19
10
0
% K
% Leu:
0
10
0
0
46
0
0
0
28
10
0
0
10
0
0
% L
% Met:
10
0
0
0
0
0
0
0
37
0
55
0
10
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
10
0
0
10
0
10
0
10
0
10
0
0
0
10
% P
% Gln:
10
0
64
0
10
0
0
19
0
10
0
55
55
10
10
% Q
% Arg:
0
0
10
0
0
0
0
19
0
19
0
19
10
10
0
% R
% Ser:
10
10
10
19
0
28
0
37
0
0
10
0
0
0
10
% S
% Thr:
0
0
0
10
10
0
0
0
10
0
0
0
0
0
0
% T
% Val:
0
0
10
10
0
0
0
0
0
0
0
19
0
10
55
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _